| Description |
Accurate control of cell cycle is essential for the formation and maintenance of a normal living organism. This course will study the molecular machinery that controls the cell cycle and the devastating consequence of its de-regulation that leads to cancer. We begin with a mechanistic examination of the cell cycle in bacteria, yeast, flies and mammals. We then consider cell cycle and cell size, and the cell cycle of stem cells. We will also discuss the oncogenic events that disrupt the normal cell cycle, the signaling pathways that activate uncontrolled cell proliferation, and the molecular therapeutics that target oncogenic pathways. |